Evaluation of saccharin as environmentally friendly catalyst for synthesis of 3, 4-dihydropyrimidin-2-(1H)-one derivatives under solvent free conditions
Maryam Rasoolzadeh - Noushin Dalaei
Maryam Rasoolzadeh - Noushin Dalaei
Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran - Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran
زبان مقاله : انگلیسی |
تعداد صفحات مقاله : 1 صفحه |
نوع مقاله : چکیده |
ISC کد مقاله در : ISC4026_524622
چکیده
Considerable number of recent researches highlights the need of a suitable catalyst in medicinal chemistry which shows high-performance in theory and practice. Literature review indicates that dihydropyrimidinones (DHPM’s) are heterocycles with a pyrimidine moiety in the ring nucleus is an important class of biologically active nitrogen containing heterocycle. These compounds in recent decades have aroused interest in medicinal chemistry due to alleged versatile biological activity. Pharmacological properties described over the last twenty-five years for dihydropyrimidinones and their derivatives compounds are reported include evaluations of anticancer, antiinflammatory, antihypertensive, antibacterial, antifungal, antiviral, antiparasitic, antithyroidic, antimuscarinic, antidiabetic, and hypolipidemic activities. In this research, we report the synthesis of dihydropyrimidinones and their derivatives through Bigineli reaction in the presence of saccharin as an organocatalyst used in three component reactions. The related procedure includes key-characteristics such as cheap, mild and environmentally friendly catalyst, high to quantitative yields and the reaction path is mild and involves facile workup procedure to obtain the desired products in short reaction times.کليدواژه ها
3, 4-dihydropyrimidin-2-(1H)-one derivatives, three component reaction, saccharin, medicinal chemistryنحوه استناد به مقاله
در صورتی که می خواهید در اثر پژوهشی خود به این مقاله ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:Rasoolzadeh , Maryam , 1398 , Evaluation of saccharin as environmentally friendly catalyst for synthesis of 3, 4-dihydropyrimidin-2-(1H)-one derivatives under solvent free conditions , دومین کنفرانس ملی کاتالیست انجمن شیمی ایران
انتشار دهنده
محل انتشار : دومین کنفرانس ملی کاتالیست انجمن شیمی ایرانمشخصات برگزارکننده همایش : دانشگاه خوارزمي
تعداد مقالات : 215
کد اختصاصی :
۹۸۱۹۱-۲۸۷۱۶
a>
دیگر مقالات این رویداد
© کلیه حقوق متعلق به موسسه استنادی و پایش علم و فناوری جهان اسلام (ISC) می باشد.