RuCl3.nH2O as Catalyst in Aldol Reaction of Isatin with Acetophenone
Elahe Keshavarz
Elahe Keshavarz
Farhangian University, Rasht, Iran
زبان مقاله : انگلیسی |
تعداد صفحات مقاله : 1 صفحه |
نوع مقاله : چکیده |
ISC کد مقاله در : ISC4026_524691
چکیده
Lewis acid catalyzed reactions belong to one of the most strong methods in modern synthetic chemistry. Among the many Lewis acids extended so far, ruthenium has attracted growing attention because of the unique combinations of their strong Lewis acidity mixed with moderation and usually high selectivity [1]. On the other hand, the aldol products form the spine of many important drugs and other bioactive molecules. The frequent incidence of a β-hydroxyl carbonyl moiety in a variety of natural products has motivate the expansion of synthetic methods for the preparation of these compounds [2]. In order to do these reactions under mild conditions, some metal ions are used as catalyst or reagent. In continuation of our continuing program to develop green synthetic protocols [3-4], we report a simple, green, and selective method for the direct one-pot synthesis of β-hydroxyl carbonyl compound using catalytic amounts of RuIII as an efficient catalyst (Fig. 1). RuCl3.nH2O is used as an efficient catalyst for synthesis of β-hydroxy unit using isatin and acetophenone. This method has potential advantages, including short reaction time, a simple work-up procedure, and clean reaction profiles. More importantly, this direct aldol reaction performs under extremely mild conditions (room temperature) to give the corresponding aldol adduct in moderate yield. Meanwhile, its catalytic performances for aldol reaction presents good activity and high diastereoselectivity. Various products are under construction with this catalytic method.کليدواژه ها
Ruthenim (III), Catalyst, Aldol reactionنحوه استناد به مقاله
در صورتی که می خواهید در اثر پژوهشی خود به این مقاله ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:Keshavarz , Elahe , 1398 , RuCl3.nH2O as Catalyst in Aldol Reaction of Isatin with Acetophenone , دومین کنفرانس ملی کاتالیست انجمن شیمی ایران
انتشار دهنده
محل انتشار : دومین کنفرانس ملی کاتالیست انجمن شیمی ایرانمشخصات برگزارکننده همایش : دانشگاه خوارزمي
تعداد مقالات : 215
کد اختصاصی :
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